β-Lactam antibiotics are most frequently used along with intravenous (IV) vancomycin hydrochloride for children with suspected serious infections. The combination of IV vancomycin plus piperacillin sodium/tazobactam sodium is associated with a greater risk of acute kidney injury (AKI) compared with vancomycin plus 1 other β-lactam antibiotic in adults. However, only a few studies have evaluated the safety of this combination for children.
The current article describes one such study which reported that administration of IV vancomycin along with piperacillin/tazobactam may increase the risk of AKI in hospitalized children. A recent study was conducted to assess the risk of AKI in children during concomitant therapy with vancomycin and antipseudomonal β-lactam antibiotic throughout the first week of hospitalization. Study design In the retrospective cohort study, the researchers focused…
