Chemotherapy‐induced peripheral neuropathy (CIPN), a common and debilitating side effect of taxane‐ or platinum‐based chemotherapy , lacks effective preventive approaches. To address this gap, a study evaluated whether a topical nociceutical formulation containing the soft vanilloid could reduce CIPN incidence and severity, involving 142 patients. The study found that the nociceutical formulation significantly reduced CIPN incidence in the hands (32% vs 13%) and increased the number of chemotherapy cycles completed without CIPN (6 vs 8 cycles).
However, a similar proportion of participants developed CIPN in the feet (73% vs 67%). Additionally, 60% of patients using the moisturizing cream reported frequently bothersome neuropathic symptoms compared with only 39% in the nociceutical group. These findings suggest that topical protection of nociceptive epidermal terminals can reduce hand…
