Alzheimer’s disease is the most common form of dementia which is highly inheritable. The genetics behind the early-onset Alzheimer’s is comparatively easier to understand since it follows an autosomal dominant inheritance pattern. The genetics behind late-onset Alzheimer’s is more complex and may also involve environmental or epigenetic influences.
September 21st, 2016 is the World Alzheimer’s Day and this article will provide insights regarding the genetic basis of the early-onset and the late-onset Alzheimer’s disease. The genetic contribution to the risk Alzheimer’s disease is till poorly understood despite major advances in identifying three genes that cause early-onset familial Alzheimer’s and one gene linked to the late-onset variety. In order to identify the predisposing genetic factor, three strategies have been proposed, the linkage analysis, gene studies, and genome-wide…
