What are Vector based DNA vaccines? Generally vaccines which utilize vectors such as bacteriophages to deliver DNA segments into the host DNA. The delivered DNA segment integrates with the host DNA and encodes for the target protein. The target protein induces a protective process by generating the necessary antibodies. DNA vaccines induce mutation after the integration of the DNA into the host? Yes it does. The concept is controversial.
The frequency of such mutation is supposedly lower than that of spontaneous mutations occurring in an individual. But workers have had difference in opinions. CpG motifs in DNA vaccine. What implications doses it have? CpG motifs or islands are short stretches of repeat of Cytosine and Guanine nucleotides found almost exclusively in Bacterial and Viral genomes. Theses are highly immunogenic evoking both innate and adaptive immunity. They are used in…
