Case presentation On self-examination, a 45-year-old woman detects a solitary, freely mobile tumor in her right breast, which is confirmed by physical examination. Mammography reveals localized calcification in the breast mass region with a linear configuration. A breast biopsy revealed large, pleomorphic epithelial cells limited to dilated ducts, with central zones of necrosis (Cover image). Question: What is the most appropriate pathologic diagnosis for this patient? A. Colloid carcinoma B.

Ductal carcinoma in situ, comedo-carcinoma type C. Medullary carcinoma D. Atypical ductal hyperplasia E. Tubular carcinoma      *This image challenge is exclusive from the editorial team of Docplexus for educational purposes only. Source: Review of Rubin’s Pathology