World Thalassaemia Day celebrated worldwide on 8 th May of every year to spread awareness about thalassaemia disease. Haemoglobinopathy is one of the most common inherited disorders. More than 70000 babies born with thalassaemia worldwide each year and there are 100 million individuals who are asymptomatic thalassaemia carriers.
The basic defect in the thalassaemia syndromes is reduced globin chain synthesis with the resultant red cells having inadequate haemoglobin content. The pathophysiology of thalassaemia syndromes is characterised by extravascular haemolysis due to the release into the peripheral circulation of damaged red blood cells and erythroid precursors because of a high degree of ineffective erythropoiesis. The purpose of this guideline is to produce evidence-based guidance on the management of women with beta (β) thalassaemia major and intermedia in pregnancy.…
