Synopsis Delirium or Acute Confusional State is a common manifestation of brain dysfunction, affecting critically ill patients admitted in the intensive care units. There are conflicting reports on whether to use antipsychotic drugs for the treatment of such patients. This week’s “ MED FACT ” discusses a Phase 3, multicenter, randomized, double-blind, placebo-controlled trial from The New England Journal of Medicine , ‘ Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness ’ Oct 2018. Authors : T.D.
Girard, M.C. Exline, S.S. Carson , et al. Key Takeaways: Administration of haloperidol or ziprasidone in critically ill patients with acute respiratory failure, shock or delirium did not significantly reduce the duration of delirium Objective: To check if there was any effect of haloperidol or ziprasidone in the treatment of delirium in patients with critical illness …
