For the first time, Cleveland Clinic researchers have discovered that diet-related molecules in the gut are linked to aggressive prostate cancer, implying that dietary changes might help to lower the risk. The study's findings were published in the journal Cancer Epidemiology, Biomarkers & Prevention. In this study, researchers analyzed the data from patients enrolled in the National Cancer Institute's Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial.
Baseline levels of key dietary components and metabolites (by-products formed when a substance is broken down in the stomach) in patients' blood serum were noted before the prostate cancer diagnosis. Then, serum levels in healthy individuals were compared with those diagnosed later with prostate cancer and who died from it. Men with elevated levels of a metabolite termed phenylacetylglutamine (PAGln) were two to three…
