Do you know the Gene Mutation Responsible for TL-DS?

Transient leukemia of Down Syndrome (TL-DS) is a hematologic disorder marked by an excessive proliferation of myeloblasts in the peripheral blood and bone marrow. It primarily affects newborns and children with Down syndrome. While the occurrence of hematological malignancies in adolescents with Down syndrome is equivalent to that of adults, the occurrence of acute myeloid leukemia in these children is 500 times higher in the first three years of life. Furthermore, 10% of infants with down syndrome develop transient leukemia. It is, therefore, essential to know the basics of TL-DS.

Test your knowledge and answer this question on TL-DS. Question: Mutation in which of the following genes results in transient leukemia of Down syndrome? CEBPA FLT3-ITD GATA1 NPM1 This question is exclusively from the Docplexus Editorial team for an educational purpose only. Stay tuned for the correct answer!…