A 50-year-old patient with acute myeloid leukemia experienced numerous complications after undergoing nonmyeloablative allogeneic hematopoietic stem cell transplant (HSCT). He underwent another allogeneic sibling peripheral blood stem cell transplant after graft failure. The transplant was successful, but he experienced chronic GVHD (cGVHD) that involved the skin, liver, eyes, and buccal mucosa. He was treated with prednisone, sirolimus, and a twice-weekly extracorporeal photopheresis (ECP). He, however, developed Mycobacterium abscessus infection and the ECP port had to be removed.
The patient was given ruxolitinib in combination with sirolimus and prednisone. He began complaining of nausea, fatigue, and headache. Initial lab work showed that his blood was lipemic with triglyceride levels >4000 (Ref. range <150 mg/dL). He was readmitted to the hospital, and an endocrinologist was…
