Nonalcoholic fatty liver disease (NAFLD) affects 30% of the global population and is strongly associated with obesity. Research has shown evidence of extensive cross-talk between the liver, immune system, metabolism and gut microbiota. According to a latest report published in Nature Medicine, metagenomic and phenomic analysis can help in identifying a gut microbiome signature that can predict NAFLD in obese women. Altered gut microbiome signature along with its metabolites can lead to the development of Hepatic steatosis in patients, especially obese women, who are at a risk of NAFLD. Reference: Hoyles, L.
et al. Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women. Nat. Med. 24, 1070–1080 (2018).
