Although the diagnostic and treatment approaches of hypothyroidism are relatively simple, a majority of patients with this condition are reported to be suboptimally treated. Even in euthyroid and hypothyroid patients on thyroid hormone replacement therapy, a substantial proportion of them experience poorer quality of life. Overview Since many years, Levothyroxine (LT4) is considered as the principal standard of care for the treatment of patients with hypothyroidism.
This is because LT4, when administered orally exhibits a long serum half-life, thereby allowing daily administration of the drug with the resolution of symptoms in the majority of the patients. However, in a small subsection of patients, the efficacy of LT4 monotherapy is suboptimal. Due to the recent advances in the understanding of thyroid physiology and pharmacogenomics, much light has been shed in determining the…
