Tumour cells have evolved in many ways to evade detection by the inherent immune cells. A team of bioengineers from Vanderbilt University devised a new technique to control the immune cells that infiltrate the tumours. They developed a nanoparticle to switch on the stimulator of interferon genes pathway (STING). Delivering these STING activating nanoparticles to the tumours increases the potential of cGAMP, thereby turning immunosuppressive tumours to immunogenic.
Hence, by unleashing the cascade to start an immune response, this system effectively destroys the cancer cells. Source: Shae, D., Becker, K.W., Christov, P., Yun, D.S., Lytton-Jean, A.K.R., Sevimli, S., Ascano, M., Kelley, M., Johnson, D.B., Balko, J.M., Wilson, J.T., 2019. Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy. Nature Nanotechnology 1.…
