Peyronie’s disease is a connective tissue disorder, characterized by the formation of a fibrotic lesion or plaque in the tunica albuginea, which further leads to penile deformity. The prevalence of the disease was found to be 9.7% and it appears to increase with age. The current article describes the guidelines specified by the European Association of Urology 2012. The guideline covers the recommendation for the patient evaluation, non-operative treatment, and surgical treatment.
Peyronie’s disease initiates with an acute inflammatory response characterized by increased proliferation of the tunical fibroblasts, some of which differentiate into myofibroblasts, with excessive deposition of collagen, the persistence of fibrin and elastin fragmentation. A prolonged inflammatory response will result in the remodeling of connective tissue into a dense fibrotic plaque. Penile plaque…
