Prader-Willi syndrome (PWS), also known as Prader-Willi-Labhart syndrome, is a genetic disorder that occurs in approximately 1 out of every 15,000–30,000 births . It equally affects males and females, irrespective of race and ethnicity. It is the most common genetic cause of life-threatening obesity in children. The syndrome occurs due to abnormalities affecting certain genes in the proximal long arm of chromosome 15, either due to deletions from the paternal chromosome or maternal disomy.
These abnormalities usually result from sporadic errors in the development of sperm or ovum. Clinical features A history of feeding difficulties is a typical sign in neonates. They may be slow with bottle feeding in the first month of life and often require gastric tube feeding. During infancy, features of mild to moderate global developmental delay are noted, along with a motor development delay…
