The low dose aspirin (LDA) has been shown to decrease the rate of overall preterm birth (PTB), likely due to a decrease in medically indicated PTB. However, there are limited data on the effect of LDA on spontaneous preterm birth (sPTB). So a trial of LDA for prevention of preeclampsia in healthy, low-risk, nulliparous women was conducted. Low-risk women were defined by the absence of hypertension, renal disease, diabetes, other endocrine disorders, seizures, heart disease, or collagen vascular disease.
Study was limited to singleton, non-anomalous gestations. Women were eligible if they had prior pregnancy terminations, but not prior spontaneous pregnancy loss <20weeks. Current pregnancies that resulted in a loss or termination <20weeks, antepartum stillbirth or had missing follow-up data were excluded. The treatment intervention was 60mg of aspirin, initiated at 13-25weeks gestation…
