Alteration of the gut microbiome with probiotics may help prevent and treat bowel cancer by reducing inflammation and suppressing colon tumours, a study in mice suggests. Researchers at University in the US found that administration of histamine-generating gut microbes reduced inflammation and tumour formation in mice which lacked that ability to produce histamine on their own. These results suggest that alteration of the gut microbiome with probiotics may become a new preventative or therapeutic strategy for patients at risk for colorectal cancer associated with inflammatory bowel disease.
In the new study, researchers investigated whether the probiotic L reuteri 6475, which is able to generate histamine, had the ability to reduce the frequency and severity of inflammation-associated colorectal cancer in mice that were not able to produce histamine on their own. The researchers…
