Synopsis In Toxoplasmosis, Spiramycin is usually prescribed for maternal seroconversions. Pyrimethamine + sulfadiazine is the treatment of choice for congenital toxoplasmosis and is used in some countries as prophylaxis. The present study compares the efficacy and tolerance of pyrimethamine with sulfadiazine vs spiramycin to reduce placental transmission of toxoplasmosis. This week’s “ MED FACT ” discusses a randomized control trial from American Journal of Obstetrics & Gynecology, “ Prenatal therapy with pyrimethamine + sulfadiazine vs spiramycin to reduce placental transmission of toxoplasmosis: a multicenter, randomized trial ”. Authors: L.
Mandelbrot et. al. Key Takeaways The rate of placental transmission was lower with pyrimethamine + sulfadiazine vs spiramycin, thus the combination appeared more effective than spiramycin alone. Objective: The present study compares the efficacy…
