Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease globally. It is characterized by the presence of hepatic steatosis (fatty liver) when no other causes for secondary hepatic fat accumulation (heavy alcohol consumption) are present. Left untreated, it may progress to cirrhosis and is likely an important cause of cryptogenic cirrhosis.
The prevalence of this condition is higher among obese and diabetic patients. Recently NAFLD has also been recognized as a risk factor for drug-induced liver injury (DILI). A study published in the journal Alimentary Pharmacology and Therapeutics has shown a reciprocal association between NAFLD and DILI, which means that drugs can cause NAFLD by acting as steatogenic factors, and pre‐existing NAFLD could be a predisposing condition for certain drugs to cause DILI - intrinsic DILI (induced by acetaminophen,…
