Randomized controlled trials (RCTs) decrease the probability for distribution bias, and therefore, the results are well-thought-out to be directly executable. These results later become the mainstay of clinical guidelines and treatments. However, one of the main problems of RCTs in critical care is that a majority of results obtained by them are negative. Furthermore, several trials interventions prove no better (or was worse) than the standard or reference control.
In the year 2008, it was reported that 62 (83%) of 75 RCTs examining mortality in critical care exhibited no advantage from the intrusion. Furthermore, from the trials with positive results, only 3 of the results are being accepted. If a statistical gaze is given to these numbers, an overall less than 5% reliability is shown for positive results of the trials. In the year 2014 analogous outcomes were observed in case of…
