Highlights It is suggested that the topical use of tranexamic acid (TXA) may provide a high drug concentration on the wound surface with negligible systemic concentrations. However, a novel approach of moistening wound surfaces with TXA before closure has been shown to reduce the drain volumes by 39% in a study of bilateral reduction mammoplasty. Such moistening exposes the wound surface to TXA for a considerably shorter time than topical boluses.
This study demonstrates that moistening the wound with TXA 25 mg/ml before closure reduces postoperative bleeding within the first 24 hours of the surgery in patients undergoing mastectomy. Authors: K Ausen, A I Hagen, H S Østbyhaug, S Olafsson, B J Kvalsund, O Spigset, and H Pleym This ‘ Journal Watch ’ summarizes the study titled “ Topical moistening of mastectomy wounds with diluted tranexamic acid to reduce bleeding: randomized clinical…
