Von Willebrand Disease (VWD) is an autosomal dominant disorder characterized by lesser or no production of Von Willebrand protein required for blood clotting. It is of two types: (i) Inherited form and (ii) Acquired form (Figure 1). The first form is again subdivided into three major types and a platelet type. Type 1 is the mildest form of the disease involving lesser production of Von Willebrand factor and/or clotting factor VIII. Type 2 is characterized by the production of non-functional Von Willebrand factors or lesser production of functional ones.
According to the international society of thrombosis and homeostasis, Type 2 is divided into four subtypes: 2A, 2B, 2M, and 2N. Type 3 VWD is the most severe and rarest form in which patients have little or no Von Willebrand factor and often have little factor VIII. Figure 1. Types of VMD (Adapted from Indian J Pharm Sci. 2011)…
