Case A 53-year-old man presented to the emergency department after a syncopal episode. History He was a regular smoker and recreational drug user and had taken heroin, cannabis, and benzodiazepine that week. In addition, he had a history of glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Examination He had grey pallor and was dyspneic at rest (respiratory rate 23 breaths per minute). His oxygen saturation was 70% on 100% inspired oxygen His blood sample was chocolate brown colored (image attached) *This Case Challenge is from the Editorial Team of Docplexus and is meant for educational purposes only. Source: The Lancet