Atropine a compound found naturally in atropa belladona and in datura, is anticholinergic and specially having antimuscarinic effect. Acetylcholine was first identified by henry dale in year of 1915 and lower confirmed it as neurotransmitter, both got nobel prize for discovery in 1936. Acetylcholine works as the neurotransmitter and as a neuromodulator and shows muscarinic and nicotinic effects on body, muscarinic receptors m1 to m5 found in heart, lung, and sweat glands. Atropine blocks muscarinic receptors thus atropine effects seen in theses organs.
Nicotinic effect predominantly is seen in skeletal muscles. Uses of Atropine: Pre-anaesthetic medication, to decrease salivation and tracheobronchial secretions, uses in dose of .4 to 6mgm/iv/im/sc prior to anaesthesia. Sinus bradycardia.5 to1mgm iv upto 3mgms. Asystole and pulseless electrical activity1mgm/iv can be repeated after 3 to 5…
