Synopsis Several open-label studies have shown that apomorphine infusion is effective in reducing off time, dyskinesias, and levodopa dose, but confirmatory evidence from double-blind, controlled studies is lacking. The present study aims to investigate the efficacy and safety of apomorphine infusion compared with placebo in patients with Parkinson’s disease with persistent motor fluctuations in a double-blind, randomized, placebo-controlled trial. This week’s “ MED FACT ” discusses a clinical trial from THE LANCET Neurology, “ Apomorphine subcutaneous infusion in patients with Parkinson’s disease with persistent motor fluctuations (TOLEDO): a multicenter, double-blind, randomized, placebo-controlled trial ”.
Authors: R. Katzenschllager et al. Key Takeaways Continuous subcutaneous apomorphine infusion has beneficial clinical effects on motor fluctuations in patients with Parkinson’s…
