Efficacy And Safety Of Omadacycline For Acute Bacterial Skin and Skin Structure Infections

Synopsis Acute bacterial skin and skin-structure infections are a significant cause of morbidity and healthcare costs. Gram-positive bacteria (Staphylococcus aureus, in particular) primarily account for most of the skin infections. Effective management of skin infections is further complicated by the emergence of antibiotic-resistant strains, especially methicillin-resistant S. aureus (MRSA).

Omadacycline, an aminomethylcycline antibiotic is known to be active against pathogens that commonly cause skin infections, including antibiotic-resistant strains. This week’s “ MED FACT ” discusses a phase 3, randomized, double-blind, multi-center study from The New England Journal of Medicine, ‘ Omadacycline for Acute Bacterial Skin and Skin-Structure Infections ’, Feb 2019. Authors : O’Riordan W, Green S, Overcash J S, et al . Key Takeaways Omadacycline was noninferior to linezolid and exhibited…