A 44-year-old Male with a past medical history (PMH) of HIV/AIDS, non-compliant with his Highly Active Antiretroviral Therapy (HAART), was admitted with upper gastrointestinal (GI) bleeding to the intensive care unit (ICU). Initially, his hemoglobin (Hgb) was 5.9 mg/dL and he was transfused 2 units of packed red blood cells (2 U PRBC). His platelet count came back as 1/mm3.

What can be the reason for this? What should be the management/ further treatment of this patient?