Thiamine (vitamin B1) was associated with improved outcomes in patients with septic shock in the retrospective study. Thiamine deficiency is often seen in critically ill patients, and lactic acidosis is a known consequence of deficiency. Thiamine treatment is safe and inexpensive, and often administered for suspected Wernicke's encephalopathy. A recent pilot study suggested benefit to supplements in patients with septic shock with documented deficiency.
Most patients received 500 mg intravenous thiamine every 8 hours for 72 hours. With vs without thiamine: Lactate clearance: subdistribution HRs from 1.292 to 1.339, based on 3 competing-risks regression models; 28-day mortality: HR, 0.666 (95% CI, 0.490-0.905); For both outcomes, women realized greater benefit than men. Retrospective matched-cohort study at an academic medical center in Lexington, Kentucky. From 1049 eligible adults with…
