A fever is a temporary increase in the body’s temperature in response to a disease or illness.Medically, it is defined as having a temperature above the normal range due to an increase in the body’s temperature set-point. There is not a single agreed-upon upper limit for normal temperature with sources using values between 37.5 and 38.3 °C (99.5 and 100.9°F). The increase in set-point triggers increased muscle contraction and causes a feeling of cold. This results in greater heat production and efforts to conserve heat.

When the set-point temperature returns to normal, a person feels hot, becomes flushed, and may begin to sweat.Body temperature is regulated by the hypothalamus. A trigger of the fever, called a pyrogen, causes a release of prostaglandin E2 (PGE2). PGE2 then, in turn, acts on the hypothalamus, which generates a systemic response back to the rest of the body, causing…