Zollinger-Ellison Syndrome (ZES), also known as gastrinoma or pancreatic ulcerogenic tumor syndrome or Z-E syndrome, is a rare disease characterized by tumor formation in the pancreas or duodenum, secreting large amounts of the hormone gastrin, causing the stomach to produce excess acid. Epidemiology Incidence rate: 0.5 to 3 out of every 1 million people/year Common in people aged 20 to 50 years More common in men Though 80% of cases are unrelated, 20-25% of cases occur associated with a rare genetic disorder called multiple endocrine neoplasia type 1 (MEN1). Etiology In most cases, the cause of the Zollinger-Ellison Syndrome is unknown.
But in 20-25% of cases, the cause is attributed to a rare genetic disorder called multiple endocrine neoplasia type 1 (MEN1), resulting in gastrinomas. Pathophysiology This disease involves the development of tumors, (or gastrinomas) within the…
